Pregnancy and SSRI's
Jul. 19th, 2012 09:14 pm![[identity profile]](https://www.dreamwidth.org/img/silk/identity/openid.png)
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Hey friends!
So my husband and I have had plans for awhile to conceive this fall. He'll be starting graduate school, I'll have a year off until I start my grad program next fall, and we'll have health insurance through school. And we've both wanted kids for a while, and we definitely feel emotionally and financially prepared for a tiny human.
I'm also taking an SSRI, 10 mg Celexa q.d., and I have been for about a year. I remember when I went to get a rx renewal back in February, I mentioned to my doctor that we were interested in getting pregnant before the end of the year. She told me about a recent study that looked at a correlation between SSRI use within a year of delivery and autism, and said that the results were fairly significant. I kind of took it with a grain of salt (because seriously everything causes autism, amirite?), and didn't really find anything conclusive. But it still kind of freaked me out that my doctor was concerned enough to tell me about it.
I'm usually pretty level-headed about things, and am pretty good at deciphering actual statistical data from news extrapolation, but I can't help but worry about this. Also, since neither one of us are in school right now, we don't have access to a journal database, which is kind of what I rely on to see original studies.
So does anyone know anything more about the SSRI/pregnancy/autism connection? How much should I trust my doctor on this? I could get off of my Celexa, but I've worked on tapering off before and it seems like 10 mg is the lowest dose I can take while still keeping my head above water, and I'm hesitant to get off of it completely because I think I owe it to my future progeny to offer them a mentally healthy mom.
Thanks!
So my husband and I have had plans for awhile to conceive this fall. He'll be starting graduate school, I'll have a year off until I start my grad program next fall, and we'll have health insurance through school. And we've both wanted kids for a while, and we definitely feel emotionally and financially prepared for a tiny human.
I'm also taking an SSRI, 10 mg Celexa q.d., and I have been for about a year. I remember when I went to get a rx renewal back in February, I mentioned to my doctor that we were interested in getting pregnant before the end of the year. She told me about a recent study that looked at a correlation between SSRI use within a year of delivery and autism, and said that the results were fairly significant. I kind of took it with a grain of salt (because seriously everything causes autism, amirite?), and didn't really find anything conclusive. But it still kind of freaked me out that my doctor was concerned enough to tell me about it.
I'm usually pretty level-headed about things, and am pretty good at deciphering actual statistical data from news extrapolation, but I can't help but worry about this. Also, since neither one of us are in school right now, we don't have access to a journal database, which is kind of what I rely on to see original studies.
So does anyone know anything more about the SSRI/pregnancy/autism connection? How much should I trust my doctor on this? I could get off of my Celexa, but I've worked on tapering off before and it seems like 10 mg is the lowest dose I can take while still keeping my head above water, and I'm hesitant to get off of it completely because I think I owe it to my future progeny to offer them a mentally healthy mom.
Thanks!
no subject
Date: 2012-07-20 03:32 am (UTC)You would get a ton of responses if you posted this to pregnant.livejournal.com
no subject
Date: 2012-07-20 03:44 am (UTC)http://www.otispregnancy.org/files/citalopram.pdf
Here's the sheet about depression: http://www.otispregnancy.org/files/depression.pdf
You can also look up other medications: http://www.otispregnancy.org/otis-fact-sheets-s13037
Hope that helps.
no subject
Date: 2012-07-20 02:19 pm (UTC)I was encouraged to wean off of Cymbalta before getting pregnant, and fortunately I was able to be okay unmedicated, but if I'd needed something, I wouldn't have hesitated to explore my options with my doctor.
no subject
Date: 2012-07-21 04:16 am (UTC)Another thing to keep in mind, OP, is that for some people pregnancy itself changes the depression picture - emotionally, hormonally. Some people find that depression vanishes during pregnancy (and returns with a vengeance after, yay) and others that it worsens. So it's probably best to have a plan in place about how to best manage depression during and after pregnancy rather than assuming that the same med and dose you're on now will be the best choice then anyway.
You can definitely find a way to manage your depression *and* the risks to your future little one. Lots of people have. :)
no subject
Date: 2012-07-20 03:53 am (UTC)Antidepressants in water trigger autism genes in fish (http://www.newscientist.com/article/dn21882-antidepressants-in-water-trigger-autism-genes-in-fish.html)
Maybe this is the study your doctor is referencing? Antidepressant use during pregnancy and childhood autism spectrum disorders (PDF file) (http://www.issues4life.org/pdfs/iariskptb034.pdf) (It's actually quite easy to find copies of journal articles listed in Medline for free, just google the journal article in quotation marks and look for a PDF link and if all else fails, email one of the lead authors and politely ask if they would sent you the file--you'd be amazed how often this works.)
no subject
Date: 2012-07-21 04:23 am (UTC)Personally, for me, this would mean weaning off my SSRI and trying other tactics for depression control pre-conception, with the intent of adding meds again if I couldn't handle it without them. But that's me, and I know my unmedicated risks.
(frozen) no subject
Date: 2012-07-20 10:29 am (UTC)Haven't you seen all the ads for class action suits against big pharm for all the babies born with defects from mental health drugs?
(frozen) no subject
Date: 2012-07-20 12:21 pm (UTC)(frozen) no subject
Date: 2012-07-20 12:21 pm (UTC)(frozen) no subject
Date: 2012-07-20 01:44 pm (UTC)I have to say I disagree with this.
If my specialist tells me I need certain drugs and instructs my GP that I am to continue with that drug on an as-needed basis even during pregnancy, then (assuming I still needed them), it really would not be common sense to stop taking them. Sure, I'd want to minimise the amounts and the number of drugs I'd need, and would carefully consider each one on its own merits, but becoming dangerously ill by not taking much-needed prescription drugs really isn't a sensible thing to do.
(frozen) no subject
Date: 2012-07-20 02:46 pm (UTC)In an ideal world, no one would have to take any drugs during pregnancy, ever. Real life doesn't work like that. With mental health issues - and even some physical conditions - you just have to weigh up the pros and cons: I know for me I've decided that staying mentally healthy through pregnancy and early parenthood is worth the very, very slight risk that the medication made affect the baby.
There's no right or wrong answer as to what is right, it is down to each individual to decide for themselves. But saying that taking medication to stay well during pregnancy is showing a lack of common sense... that's unfair.
(frozen) no subject
Date: 2012-07-20 03:06 pm (UTC)(frozen) no subject
Date: 2012-07-20 03:32 pm (UTC)(frozen) no subject
Date: 2012-07-20 03:42 pm (UTC)For what it's worth, I am on a very high dose of celexa, and my team of doctors agreed that I should stay on my meds if I successfully got pregnant. There are risks and benefits to every single decision anyone makes ever.
(frozen) no subject
Date: 2012-07-20 04:07 pm (UTC)(frozen) no subject
Date: 2012-07-20 03:49 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:34 pm (UTC)(frozen) no subject
Date: 2012-07-20 03:54 pm (UTC)Can you explain this more? If the person actually can't go nine months without the pills, then what other way would there be?
(The nine month figure is also misleading. Multiply that nine months by the number of pregnancies the person has, and add time trying to conceive and time breastfeeding to that so that you end up with several years in some cases.)
"The risks of harm to the fetus, to me at least, would be far too great."
There are known risks of unmedicated depression. The risks of harm to the fetus, to me at least, would be far too great.
(frozen) no subject
Date: 2012-07-20 04:03 pm (UTC)Now perhaps you think that women like me shouldn't have children - but that's not your call to make. As a healthcare provider, your duty should be what is best for mother and baby.
(frozen) no subject
Date: 2012-07-20 04:07 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:08 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:11 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:32 pm (UTC)Like you said about "sensitive issues" - it is for me as well. I am hotly against ANY questionable substances during the duration of a pregnancy. I do understand there are risks and benefits both ways - parent and child. I think if someone wants to be a parent bad enough, they would do whatever it took to ensure a healthy and normally developing fetus. If you think I'm being pushy or trying to ram this belief down others' throats, I am sorry you misconstrued my posts, because that was not my intention.
(frozen) no subject
Date: 2012-07-20 04:49 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:16 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:52 pm (UTC)(frozen) no subject
Date: 2012-07-20 05:36 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:41 pm (UTC)(frozen) no subject
Date: 2012-07-20 04:56 pm (UTC)I absolutely do not mean to say to the OP that she's horrible if she does take her meds or that she shouldn't be a parent if she's someone with a mental illness - but I do mean to say those in such situations are going to have to put a lot more preparation and care and research into such an endeavor as carrying and parenting a child. And again I'll stress that it's kinda personal too - my birth mother (don't know her) used mental health drugs and street drugs in her pregnancy with me and I have three birth defects - webbed toes, Crouzone's syndrome (look it up, pretty interesting stuff actually) and I'm an XY/XO Turner's hermaphrodite. Thank God my brain and IQ are ok!
Basically what I mean when I say that - and talk about my work experience - is a huge red flag goes off along with alarm bells in my head when we're talking psychotropics and pregnancy. In my clinical understanding though, I know a fair and balanced evaluation based on the person's individual needs and circumstances must be conducted.
(frozen) no subject
Date: 2012-07-20 05:49 pm (UTC)The risk/benefit analysis is one each potential pregnant person must make individually, based on scientific evidence and advice from health care providers and also personal values and beliefs. Different people will feel differently about certain degrees of risk, and also about risk of different conditions assosciated with different medication exposures, and it is my job to give information and support decisions, not to make decisions on behalf of other people.
(frozen) Maintainer Note - Safe Space Warning
Date: 2012-07-21 07:37 pm (UTC)We're commenting because your attitude and wording in this comment and in other comments in this discussion thread do not foster what we consider safe space (http://wiki.vaginapagina.com/index.php?title=VaginaPagina_FAQ#Safe_Space) here in the community.
Saying that it's "a rule of thumb (and common sense)" not to take prescription medication while pregnant comes across as judging people who choose to do so; the implication is that, because they are making decisions that you do not approve of and would not make yourself, they lack common sense, and that's not appropriate in this community.
We're concerned about the implied and outright judgment in your other comments. Saying "If someone can't go nine months without taking pills, find another way," and "I think if someone wants to be a parent bad enough, they would do whatever it took to ensure a healthy and normally developing fetus" is inappropriate because it's dismissive and disrespectful of those who have conditions that require medication, as it implies that their legitimate medical need is a careless or imprudent choice and evidence that they don't "want to be a parent bad enough."
Similarly, saying things like "In short, these women are incapable of parenting due to their illnesses and their bodies are incapable of supporting a pregnancy because of the medicines they need to function as normally as possible," makes some sweeping, negative generalizations not only about the ability of those with mental illness to be parents, but also about the quality of their lives as compared to neurotypical people.
We're also concerned that your statement in this comment (http://vaginapagina.livejournal.com/21032796.html?thread=245212764#t245212764) that you're thankful that your "brain and IQ are okay," may be deeply upsetting and offensive to those with developmental disabilities -- while the way they function may be different, it doesn't mean that they're not okay, or that neurotypical/nondisabled people have the right to make such comments.
Finally, we want to point out our policy on misinformation (http://wiki.vaginapagina.com/index.php?title=VaginaPagina_FAQ#What_is_misinformation_and_why_does_it_matter_in_VP.3F), specifically as it applies to sharing personal experiences. While we appreciate that the information you have shared here is your personal experience, you've couched it in such terms that a reader might take it to mean that the majority of people who use psychiatric drugs in pregnancy experience the type of adverse outcomes you describe. This is an unsourced and unsupported claim that is not backed up by current medical research.
We appreciate that you acknowledge here (http://vaginapagina.livejournal.com/21032796.html?thread=245212764#t245212764) that such decisions are best reached via individual evaluation (with professional support), but we feel that your other comments and claims in this thread fail to take this into account.
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You are more than welcome to make a post over in
Jocey
for the VP Team (http://www.vaginapagina.com/contact.php)
no subject
Date: 2012-07-20 03:26 pm (UTC)Celexa is a pregnancy category C, which means, in short, that it isn't ideal in pregnancy. HOWEVER, that doesn't mean that every woman should stop taking it when she gets pregnant! Mental health plays a HUGE part in maternal-fetal outcomes. So, it's really important that you consider the benefit that taking Cymbalta has on your life--and that isn't something that anyone here can evaluate for you (obviously, and I know you aren't asking us to!).
Zoloft is the only SSRI FDA-approved for safe use in pregnancy (and breastfeeding). Because the evidence is so insufficient, I think you could poll doctors and midwives and STILL not get a consensus about what is safe, you know? I searched EBSCO, and I found a study that discusses hyperserotonemia and its hypothesized link to neurological functioning in rats, but that's pretty much all that I found when searching "SSRI and PREGNANCY and AUTISM".
Long story short? I don't know that the evidence is compelling enough to drop the Celexa. But it might be worth considering, if the potential risks are greater than the potential benefits during pregnancy. Do you think it would be worthwhile to get another opinion from another doctor or nurse practitioner?
no subject
Date: 2012-07-24 09:57 am (UTC)no subject
Date: 2012-07-20 09:48 pm (UTC)Attempting to rewrite my comment...
I think a lot depends on what you're prepared to deal with and how concerned you really are about the possible connection. I'm sure you could find plenty of autistic people whose mothers didn't take SSRIs while pregnant, and lots of non-autistic people whose mothers did take them. One study is really only one study. Also, there may be another SSRI you could take that would work just as well and be safer than Celexa.
Autism really isn't The End - it will change your plans and your life, for sure, but if you know it's a possibility you can do some research and be totally prepared if your child is diagnosed with it.
I remember watching a segment on a news program about a couple that found out that their daughter was going to born with a form of Dwarfism, so they researched the condition and were prepared with all kinds of supports for her when she was born. As a result, her communication skills were leaps and bounds ahead of her same-age peers since they chose to focus on that while her motor skills were catching up.
Since the best things you can do for an autistic preschooler are the same things you would do for a non-autistic preschooler (just a bit more intense), you probably wouldn't be looking at a lot of huge differences at first anyway.
Obviously everyone's experience is going to be different. What I know is that, in the families I worked for (when I worked with autistic children), the children who were happiest and the parents who were the least stressed were the families that focused on what was best for each child and not how hard it was to get services/the right services for the autistic child. One family in particular, the youngest daughter was autistic and the daughter two years older than her was gifted. The older girl was placed in split classes at school where she was in the younger grade, so she was constantly challenged. Meanwhile, the younger girl had a full-time aide to help her participate in her class activities. She just graduated from grade 12. I haven't been in touch to find out what's next for her, but I'm sure it will be something she loves, "even though" her speech is stilted and very marginal and she has difficulty with most language-based activities.
Thank you for bringing this up, by the way. I have ADHD, and I'm going to have to stop taking my Adderall when my husband and I decide to start trying to get pregnant. I'm not looking forward to it, but there's absolutely no option for me on that count.
Rambling, Part 1 (I often exceed the comment limit...)
Date: 2012-07-22 03:53 am (UTC)Disclaimer/bias: My kid is diagnosed with Asperger's (extremely high-functioning ASD; she's also extremely bright), and shares nearly all those traits with her dad (and the one that he doesn't quite have, his mom does). I'm not going to say that it's easy to raise her; neurotypical and bright would be loads easier. On the other hand, what I regret most is not getting her diagnosed earlier, or put into the classes she's in earlier. (http://www.socialbridges.com/ -- they have links to other sites, which may be a useful resource.)
Anyway, from what I have read...
It is entirely possible that certain medications and drugs might trigger or enhance the genetic expression of ASD; we don't know enough about it yet, I think. It's also possible that some drugs might cause brain damage or developmental delays. (Like hypothyroidism, untreated, has the potential to cause fetal brain damage... Meh.) It's certainly worth researching specific stuff!
I found (with a search on Celexa pregnancy autism site:gov)...
• http://www.ncbi.nlm.nih.gov/pubmed/21727247 ("Although the number of children exposed prenatally to selective serotonin reuptake inhibitors in this population was low, results suggest that exposure, especially during the first trimester, may modestly increase the risk of ASD. The potential risk associated with exposure must be balanced with the risk to the mother or fetus of untreated mental health disorders. Further studies are needed to replicate and extend these findings.")
• Mind, http://www.nlm.nih.gov/medlineplus/news/fullstory_125676.html says that maternal fever can increase the chance of autism. (Perhaps the high heat causes more copy errors in the genes of the cells as they develop in the first trimester? That article does say that those who took fever-reducing meds had "had similar risks as those moms who did not run a fever during their pregnancy.")
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312583/ is... extremely dense with medical terminology. I think the key part is in the Abstract: "administration of SSRIs during a sensitive period of brain development results in long-lasting alterations".
Rambling, Part 2
Date: 2012-07-22 03:57 am (UTC)You may want to find an expert in early interventions that can raise functioning (severe autism can be very difficult; moderate to mild points on the spectrum may be "high needs" in some ways, but aren't nearly so stressful), and learn what you can do to ameliorate the negative effects of ASD, appreciate the positive ones, and provide explicit teaching for a kid who might not absorb stuff the way neurotypical ones do. And, for that matter, how to recognize the signs that you might need to do that early intervention.
If you do have a family history of ASD, you may wish to consider if you are in a good place to have a high-needs child. Even with our extremely bright (she got an IQ test when she was diagnosed) kid, there are challenges. We drive our kid to her Social Skills appointments once a week, and it's an hour away. We have an IEP for her at school, and I've had to pull her out of a classroom with a bullying teacher who seemed to think it was okay to shame a kid with delayed-developmental control of her emotions, for crying, when one would hope that teacher wouldn't dare shame a child born without legs for not walking. I have to explain stuff to her that a neurotypical kid would probably pick up instinctively. (On the plus side, she views many unconscious neurotypical assumptions as extremely illogical and to be challenged (she's right...); she's very inclined to follow family rules (if she understands the reasons behind them); she's extremely truthful; and she's amazingly full of empathy for... well, everyone! (As soon as she realizes their point of view, of course; she's a kid, and can be self-centered like any other kid.))
And, again, only Y'ALL can decide if you are in a place where a high-needs kid would be something y'all could manage, and if someone would have unbearable resentment or self-identity issues if it turned out that someone had to be a primary care-giver 24/7 for longer than expected. (And, really, even when there are no risk factors? Sometimes stuff happens. This sort of "weigh the risks, weigh what we can handle, evaluate the extreme ends but don't obsess over them" is... Well, you've probably done some of this at least already, betcha. O:> )
(Again on my biases:
• iahp.org -- Glen Doman's "Teach Your Baby To Read" saved my stability when the kid was much younger. You're only supposed to flash the word-cards for maybe 5-15 seconds at a time, but I remember one night with a fussy baby where I probably did it for a few minutes at a time, with a huge stack of word-cards, because she would sit on my lap and stare in fascination and not fuss! She was reading very early, and considering that she is an attention-demanding extrovert and I'm an introvert... Spoons, I do not have as many as she wants! Books, they entertain her! Still do, too.)
• And thyroid testing! Untreated hypothyroidism has fetal brain damage risks, and I really, really would have liked to have known that my thyroid sucked before I got pregnant, and not years after! I lucked out, BUT! Also, pre-eclampsia stinks.)
Anyway, I hope that I've said everything optimally (... probably not; it's late here... sorry!!), and am wishing you good luck!