Can Astroglide cause a yeast infection? Astroglide will not cause a yeast infection, however, there have been several women's journals citing glycerin as a source of yeast infections. This is not true! In fact, some yeast infection cures contain glycerin. An existing yeast infection can be made worse by using products containing a large percentage of glycerin. This is because the sugars in glycerin act as a food source for the yeast. Women who are prone to yeast infections should use a lubricant that does not contain glycerin.