I've been on depo over six months. Lots of women love depo, lots hate it. If your body doesn't take to it, you can bleed/spot erratically for months. I've been spotting for almost three months. I've gained almost 10 pounds using depo and I wouldn't be surprised if I keep gaining. It has really increased my appetite. So even though I try to eat right, I slip pretty often because I'm hungry pretty much all the time. It does cause bone loss, so calcium supplements are a must.

That being said, not having to worry about birth control for three months at a time is worth it to me. And it is very effective against pregnancy. The weight gain does not bother me or my partner. The spotting is very often not even enough to require a panty liner. In the end, I love my depo. :)