There's really no pill with low side effects, every woman's experience is different, and what works for me may not for you and vice versa. My roommate experienced depression the first cycle or two she spent on HBC, but it passed after that. So mood changes are definitely a side effect to keep an eye out for; doctors often suggest giving a pill three months to see if the side effects go away, so if you want to wait it out, it may go away. But mood changes aren't an easy thing to deal with, and if you decide you don't want to give it three months, describe what happened to your doctor, and you can talk about other brands of HBC to try or an IUD. :)