I know that not every remedy works for every body BUT, I know a few girls with PCOS who have been helped a lot be Metformin. (Not sure of the spelling.) My closest friend has had irregular periods since the beginning. She was underweight until she was in her twenties and is now twenty-six, slightly over-weight and still they were crazy irregular, like three to fourteen months irregular. This Spring she was put on Metformin, has been mensing every six weeks and lost twenty pounds.