I remember writing an entry about my nightmare with depo. I am sure you could find it by searching the memories on here. A quick synopsis: I had no interest in sex, gained 20 pounds in two months, and wanted to kill myself. I felt completely out of character on it and I would never go back to it. I only had 2 shots and that was more than enough for me. Of course, it's pretty varied from one person to the next, but I had so many women comment that they had similar experiences on that entry.

I agree with the person that said there's a red flag here. Depo is known to cause mood swings, so definitely watch out for that or if you just feel something isn't right. Depo, when used correctly, is a very effective form of bc, but I am not sure whether your medications will interfere with it. I would ask your provider.

That said, I don't mean to scare you. I had a bad experience with it, but some women LOVE it.